STANDARD V14.4 • ROUTAGE O(1) 24-pole relational architecture & 17 Index-Experts™ synchronized with NCBI 2026 taxonomy, EBI SIFTS 3D and cFMD/FMBN.
🎛️ Profile Selection & Cognitive Granularity (0 ms) 🧬 Palier 5 — Expert Absolu
1 5
🔎 Click any sourced badge to verify its proof
🎛️ Cognitive Granularity Slider (Progressive Disclosure 1 → 5)
Click any tier (1 to 5) to instantaneously filter the displayed scientific depth:
Palier 1 • Identité NCBI 🦠 NCBI TAXID #224914 • STRAIN • Bacteria 🔎 NCBI Certificate #224914
← Back to portal

Brucella melitensis bv. 1 str. 16M Brucella melitensis (Hughes 1893) Meyer and Shaw 1920 (Approved Lists 1980) emend. Verger et al. 1985

🌍 Brucellosis pathogen (Malta fever agent) ; Agent pathogène de la brucellose (fièvre de Malte)

⚡ 3 active Index-Experts™ pole(s) (O(1) routing)  •  🧀 0 linked cheese matrix/matrices  •  🧊 25 3D structure(s) RCSB PDB / EBI SIFTS

🌳 Phylogenetic Lineage & Associated Cheese Matrices

Palier 2 • Fromager & Sommelier
Pseudomonadota (phylum) › Alphaproteobacteria (class) › Hyphomicrobiales (order) › Brucellaceae (family) › Brucella (genus)

🧫 Isolation Substrates, Biological Hosts & Cellar Ecology (NCBI Host)

Palier 3 • Praticien & Affineur
Fromages frais et pâtes molles au lait cru de brebis et de chèvre
INDEX-EXPERT™ #01 • Tyrodexia™ Architecture Palier 5

Synonyms and historical names (NCBI)

🔎 SQLite Proof
Nomenclature concordance (NCBI) Brucella melitensis bv. 1 str. 16M ⟷ Brucella melitensis ATCC 23456
Historical synonyms & basionyms Brucellosis pathogen (Malta fever agent) ; Agent pathogène de la brucellose (fièvre de Malte) • Bacteria
Taxonomic authority & reference strains Brucella melitensis (Hughes 1893) Meyer and Shaw 1920 (Approved Lists 1980) emend. Verger et al. 1985
Official sources & reference book TaxID:224914 • Le grand dictionnaire du microbiome des fromages (https://www.tyrodexia.com/index.html#ouvrage)
Lineage & phylogenomic justification Pseudomonadota (phylum) › Alphaproteobacteria (class) › Hyphomicrobiales (order) › Brucellaceae (family) › Brucella (genus)
PubMed taxonomic references PMID:24657159 🔎 • DOI:10.1016/j.ijfoodmicro.2014.02.016 🔎
INDEX-EXPERT™ #06 • Tyrodexia™ Architecture Palier 3

Symptoms and manufacturing defects

🔎 SQLite Proof
Vigilance category & defect diagnosis Agent pathogène de la brucellose (fièvre de Malte) • Absence totale de signe visuel ou olfactif sur le fromage ; zoonose majeure réglementée provoquant une fièvre ondulante septicémique
Spoilage metabolites & taxonomic lineage Excrétion directe dans le lait par la glande mammaire infectée et résistance à la phagocytose ainsi qu'à l'acidification modérée des pâtes fraîches
Documented substrates & historical synonyms Statut officiellement indemne des cheptels ovins/caprins, pasteurisation du lait ou affinage prolongé (> 60 jours avec acidification lactique stricte) • Lait cru issu de troupeaux non indemnes, pH > 5.0, affinage court (< 60 jours), survie intracellulaire dans les leucocytes du lait
Official sources & reference book TaxID:224914 • Le manuel clinique des pathologies laitières et fromagères (https://www.tyrodexia.com/index.html#collection)
Reference strain collections ATCC 23456, NCTC 10094, CIP 104252 (Souche 16M)
Operator safety & PubMed references PMID:24657159 🔎 • DOI:10.1016/j.ijfoodmicro.2014.02.016 🔎
INDEX-EXPERT™ #08 • Tyrodexia™ Architecture Palier 4

Pathogens and bioprotection

🔎 SQLite Proof
Bacteriocins (NPClassifier) & health targets Brucellosis pathogen (Malta fever agent) ; Agent pathogène de la brucellose (fièvre de Malte) • Bacteria
Isolation substrates & linked cheese matrices Fromages frais et pâtes molles au lait cru de brebis et de chèvre • Pseudomonadota (phylum) › Alphaproteobacteria (class) › Hyphomicrobiales (order) › Brucellaceae (family) › Brucella (genus)
Physicochemical barriers (TDM, moisture, NaCl USDA) Brucella melitensis (Hughes 1893) Meyer and Shaw 1920 (Approved Lists 1980) emend. Verger et al. 1985 • Brucella melitensis ATCC 23456
Official sources & reference book TaxID:224914 • Le manuel clinique des pathologies laitières et fromagères (https://www.tyrodexia.com/index.html#collection)
Prophylaxis & PubMed references PMID:24657159 🔎 • DOI:10.1016/j.ijfoodmicro.2014.02.016 🔎

🏛️ Global Culture Collections (DSM / ATCC / CBS), NCBI Synonyms, Strains & FAO DAD-IS Breeds

Palier 4 • Institutionnel & Microbiologiste
NCBI Synonyms & Basionyms Brucella melitensis ATCC 23456
🔬 Subordinate strains and subspecies qualified in Tyrodexia™ (2) :
🦠 Brucella melitensis 16M13W #1143191 🦠 Brucella melitensis 16M1W #1143190

🧬 RefSeq Genomics, 3D Structural Biology (EBI SIFTS), Metagenomics (cFMD/FMBN) & PubMed

Palier 5 • Expert Absolu
EBI SIFTS / RCSB PDB 3D Structures PDB #1TM0 (25 crystallographic structures • CIF) — RCSB PDB 3D ↗
NCBI RefSeq Genomic Assembly RefSeq: GCA_000007125.1 • Taille: 3.29493 Mb • GC: 57.2357 % • Statut: Complete Genome • BioSample: SAMN02469571 • BioProject: PRJNA82685
PubMed / DOI Primary Literature PMID:24657159 🔎 • DOI:10.1016/j.ijfoodmicro.2014.02.016 🔎